A number of reviewers have queried what "sex is on fire" means, with many opting for burning venereal disease. Lead vocalist Caleb Followill joked on his.
However, it has also been postulated that the song is about that transmission of STDs, due to the Kings of Leon actually joking about such. According to Kings of Leon band member Nathan Followill, the song had nothing to do with sex. The entire Kings’ of Leon clan (Caleb.
"Sex on Fire" as written by and Jared/followill Followill. .. way he sings it, your SEX is on fire! he just means it so much, and there is so much feeling behind it.